However, these values can be further modified by being multiplied by an affinity size scalar: Size There are four different reactions a companion can have towards the player character's actions/dialogue that will affect their affinity value: For most companions, a new dialogue will be triggered when the affinity value reaches 250, 500, 7. If the affinity value drops further, they will become angry and refuse to travel with the Sole Survivor. Lowering the affinity to a sufficiently negative value will displease the companion, and they will issue a single warning to the Sole Survivor, asking them to change ways. Raising their affinity to 1000+ (max is 1100) will result in them "idolizing" the Sole Survivor, at which point the Sole Survivor is granted their companion perk. If the affinity value reaches 500, they will "admire" the Sole Survivor and often reveal new dialogue. The affinity value is a hidden statistic, meaning it is not possible to check the progress without console commands.Īll companions begin at an affinity value of 0. Reaching maximum affinity with a companion will unlock a special perk. ![]() ![]() Raising the affinity value grants additional dialogue into their history or the possibility of romance. Actions or dialogue that please one companion may displease another. Each companion has a distinct personality and values. Companions can develop personal connections to the Sole Survivor and some may ask for help with quests of their own.
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![]() Automatic preview thumbnail galleries of your imagesThe versions provided below are of StuffIt Classic. What is StuffIt Deluxe 1.5.x - 8.x StuffIt was the most versatile and used compression suite on the Mac since 1987.Archive photos and files directly to FTP.Search for files within Zips and StuffIt archives by name, date, and more.Deluxe added a variety of additional functions, including additional compression methods and integration into the Mac Finder to allow files to be compressed from a "Magic Menu" without opening StuffIt itself. ![]() They split the product line in two, offering StuffIt Classic in shareware and StuffIt Deluxe as a commercial package. StuffIt soon became very popular and Aladdin Systems was formed to market it (the last shareware release by Lau was version 1.5.1). And with the most comprehensive array of translators and decoders available, StuffIt Deluxe easily makes exchanges with other Macs, PCs, or Unix-based computers. By the fall of 1987 StuffIt had largely replaced PackIt in the Mac world, with many software sites even going so far as to convert over existing PackIt archives to save more space. Compared to existing utilities on the Mac, notably PackIt, StuffIt offered "one step" operation and compression ratios that could not be matched. It combined the fork-combining capabilities of utilities such as MacBinary with newer compression algorithms similar to those used in ZIP. StuffIt was originally developed in the summer of 1987 by Raymond Lau, a high school student at Stuyvesant High School in New York City. What is StuffIt Deluxe 10.0 StuffIt Deluxe 10.0 with serial number, runs on Mac OS X 10.3 and higher on PowerPC processors (i.e. Compress Everything Agency: Saatchi & Saatchi / New York Category: Consumer Magazine. StuffIt Deluxe es una completa herramienta de compresión compatible con la mayoría de formatos y realmente fácil de usar. The proprietary compression format used by the StuffIt utilities is also termed StuffIt. StuffIt is a family of software utilities for archiving and compressing files on the Apple Macintosh, Microsoft Windows and Linux platforms: it was originally produced for the Macintosh and remains common on that platform. The much-anticipated cinematic return of the global phenomenon reunites the beloved cast as they. “The Gilded Age” debuts Monday, January 24 at 9pm ET and will be available to stream on HBO Max. From award-winning creator Julian Fellowes comes the motion picture event DOWNTON ABBEY: A NEW ERA. ![]() We want viewers to experience and marvel at the progress of that moment but to also understand the very real hurdles that existed for many Americans.” The show takes place in late 19th century America when the country was moving into a modern era. We want viewers to feel and see a landscape that is from the past yet believable and accurate. “Viewers will see these different worlds and be able to connect the past to the present.”ĭunbar continued, “While ‘The Gilded Age’ is a fictional show, it’s important to ground the storytelling in authenticity. Erica Armstrong Dunbar recently told Entertainment Weekly about the series. “While it was a period of expansive wealth and great opulence for a small segment of Americans, it was also a time when social inequities were glaring,” the series’ co-executive producer and historical consultant Dr. ‘How To with John Wilson’ Is One of HBO’s Best Shows - So Why Is It Ending? Accompanied by Peggy Scott (Benton), an aspiring writer seeking a fresh start, Marian inadvertently becomes enmeshed in a social war between one of her aunts, a scion of the old money set, and her stupendously rich neighbors, a ruthless railroad tycoon and his ambitious wife, George (Spector) and Bertha Russell (Coon).” Against the backdrop of this transformation, the series begins in 1882 with young Marian Brook (Jacobson) moving from rural Pennsylvania to New York City after the death of her father to live with her thoroughly old money aunts Agnes van Rhijn (Baranski) and Ada Brook (Nixon). HBO’s official synopsis for “The Gilded Age” reads: “The American Gilded Age was a period of immense economic change, of great conflict between the old ways and brand new systems, and of huge fortunes made and lost. The nine-episode first season debuts in January with an ensemble cast that includes Carrie Coon, Morgan Spector, Denée Benton, Louisa Jacobson, Taissa Farmiga, Blake Ritson, Simon Jones, Harry Richardson, Thomas Cocquerel, Jack Gilpin, Cynthia Nixon, and Christine Baranski. ![]() “Downton Abbey” creator and “Gosford Park” screenwriter Julian Fellowes is set for a rousing start to 2022 with the release of the “Downton Abbey” film sequel (subtitled “A New Era”) in March and now the launch of his next period television series “ The Gilded Age.” HBO has premiered the first trailer for the 19th-century class warfare drama. ![]() ![]() COPD-related cerebrovascular damage has been implicated, with studies showing that impaired lung function is associated with cerebral white matter lesions ( 13, 14) and the presence of widespread white matter microstructural damage in stable COPD ( 15). Hypoxemia, systemic inflammation, oxidative stress, sympathetic nervous system activation, accelerated aging, and autoimmunity are a selection of plausible pathophysiological mechanisms for brain pathology and cognitive dysfunction in COPD ( 12). In addition, there appears to be a dose–response relationship between COPD duration of more than 5 years at baseline and risk of mild cognitive impairment ( 11). A self-reported diagnosis of COPD in mid-life has been found to be independently associated with subsequent cognitive impairment (hazard ratio, 1.85) ( 10). Mild cognitive impairment has been shown in 36% of patients with moderate to severe COPD (vs. Understanding of the mechanisms that result in cognitive problems and their clinical impact remain incomplete in COPD. Importantly, cognitive ability is critical for self-management and education, which underpin effective care ( 8). It has been suggested that impaired cognition may also be a predictor of mortality and disability in certain COPD populations ( 6, 7). ![]() Impairments are often global but most commonly involve executive functions, memory, and attention ( 4, 5). Cognitive impairment has been demonstrated in cross-sectional studies of COPD, with moderate to severe impairment in up to 57% of patients hospitalized because of an exacerbation ( 1). The potential impact of COPD on cognitive ability has an emerging clinical relevance ( 1– 3). It is plausible that cerebrovascular comorbidities explain previously described cognitive pathology in COPD.Ĭhronic obstructive pulmonary disease (COPD) is a complex, multisystem disorder. There was no association between executive function impairment and frequency of hospitalization, and there was a possible modest association with survival. Lung function, Pa O 2, smoking, survival, and hospitalizations were not significantly different in those with executive dysfunction.Ĭonclusions: In this large population of patients with severe emphysema and heavy cigarette smoking exposure, there was no significant decline over 2 years in cognitive executive function as measured by TM tests. ![]() Changes in TM scores were not associated with frequency of hospitalization. Changes in TM B times were modestly associated with survival, but changes in TM B − A times were not. There was no significant change over 2 years in TM A or B times after adjustment for covariables. George’s Respiratory Quotient, reduced well-being, and lower social function. Compared with those who did not, these patients were older, less educated, had higher oxygen use, higher Pa CO 2, worse quality of life as measured by the St. At the time of enrolment, 38% had executive dysfunction. Measurements and Main Results: The average age of the patients was 66.4 years, and the average FEV 1 was 23.9% predicted. Associations with survival and hospitalizations were examined using Cox regression and linear regression models. To assess executive function, we analyzed trail making (TM) A and B times at enrollment in the trial (2,128 patients), and at 12 (731 patients) and 24 months (593 patients) after enrollment, adjusted for surgery, marriage status, age, education, income, depression, Pa O 2, Pa CO 2, and smoking. Methods: This study was performed on patients enrolled in the National Emphysema Treatment Trial. Objectives: We examined longitudinal changes in sensitive measures of executive function in a well-characterized population of patients with severe COPD. Rationale: Cognitive dysfunction has been demonstrated in chronic obstructive pulmonary disease (COPD), but studies are limited to cross-sectional analyses or incompletely characterized populations. ![]() In a recent clinical application study, the assay also resulted in improved prescription of antimicrobial therapy, a reduction in isolation days of admitted patients, and detection of pathogens that were not requested to investigate by the clinician. The GenMark Respiratory Pathogen Panel (RPP) assay on the ePlex instrument was evaluated in several clinical studies and showed excellent overall agreement of over 95 % compared to laboratory-developed (multiplex) real-time PCR assays (LDTs) in samples with cycle threshold (C T) values < 35. These assays are able to rapidly detect multiple pathogens associated to clinical syndromes, including viruses, bacteria and parasites. There is substantial progress in the development of syndromic testing platforms for respiratory infections, gastroenteritis and even neurological infections. ![]() Some bacterial pathogens, like Legionella pneumophila, are critical to detect because they represent important epidemiologic challenges and can cause serious complications that require treatment strategies different from standard empiric regimens. The clinical performance of both assays depended highly on the bacterial load in the sample and the type of specimen under investigation.Ĭommunity-acquired respiratory tract infections are a leading cause of hospitalization worldwide and a significant cause of mortality, especially in vulnerable patient groups. No false-positive results were reported for all three bacterial pathogens by both assays. pertussis positive samples and 13/15 (86.7 %) of the M. ![]() pneumophila targets, 8/12 (66.7 %) of the B. The ePlex Respiratory Pathogen Panel (RPP) assay detected 10/14 (71.4 %) of the L. pertussis positive samples but only 11/15 (73.3 %) of the M. The QIAstat-Dx Respiratory Panel V2 (RP) assay detected all of the L. Fifty-six specimens were collected from our repositories, five negative samples and fifty-one samples which had been previously tested positive with the routine diagnostic real-time PCR assays for Legionella spp. Aim of this study was to evaluate the performance of these syndromic panels for these three bacterial targets in samples from the LRT. For diagnosing bacterial pneumonia, lower respiratory tract (LRT) specimens are indicated. The assays have been marketed for use in nasopharyngeal swab specimens. The ePlex® and QIAstat-Dx® respiratory pathogen panels detect multiple respiratory pathogens, mainly viruses but also Legionella pneumophila, Mycoplasma pneumoniae and Bordetella pertussis. ![]() Store it at room temperature and away from excess heat and moisture (not in the bathroom). Keep this medication in the container it came in, tightly closed, and out of reach of children. ![]() Older adults should not usually take dimenhydrinate because it is not as safe or effective as other medications that can be used to treat the same condition. talk to your doctor about the risks and benefits of taking dimenhydrinate if you are 65 years of age or older.Dimenhydrinate chewable tablets contain aspartame that forms phenylalanine. if you have phenylketonuria (PKU, an inherited condition in which a special diet must be followed to prevent damage to your brain that can cause severe intellectual disability), read the package label carefully before taking dimenhydrinate.Alcohol can make the side effects from dimenhydrinate worse. avoid alcoholic beverages or products containing alcohol while taking dimenhydrinate.Do not drive a car, operate machinery, or participate in potentially dangerous activities until you know how this medication affects you. you should know that dimenhydrinate may make you drowsy.if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking dimenhydrinate.If you become pregnant while taking dimenhydrinate, call your doctor. talk with your doctor if you are pregnant, plan to become pregnant, or are breast-feeding.talk with your doctor if you have or have ever had asthma shortness of breath or difficulty breathing, including chronic bronchitis (swelling of the air passages that lead to the lungs) or emphysema (damage to air sacs in the lungs) difficulty urinating due to enlargement of the prostate (male reproductive organ) glaucoma (an eye disease that can cause vision loss) or seizures.Your doctor may need to change the doses of your medications or monitor you carefully for side effects. ![]() Be sure to mention any of the following: aminoglycoside antibiotics such as such as amikacin (Amikin), gentamicin (Garamycin), kanamycin (Kantrex), neomycin (Neo-Rx, Neo-Fradin), netilmicin (Netromycin), paromomycin (Humatin), streptomycin, and tobramycin (Tobi, Nebcin) antidepressants such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adapin, Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil) antihistamines, such as diphenhydramine cough and cold medications ipratropium (Atrovent) medications for anxiety, irritable bowel disease, mental illness, Parkinson's disease, seizures, ulcers, or urinary problems narcotic or strong pain relievers or muscle relaxants sedatives sleeping pills and tranquilizers.
![]() All White Out games are showcased with an advanced fireworks display lining the east and west (long ends) of Beaver Stadium. It has been described as "the best atmosphere in college football." It is also among the most expensive regular season games of college football, with ticket prices ranging upwards of $250. The White Out is a tradition at the Pennsylvania State University during select Nittany Lions home football games, where all spectators come dressed in white. Shot by PSU MacBean, Kaitlyn, bottom left, saved by Murphy, Maddie.Not to be confused with Winnipeg White out. Shot by PSU Kershner, Elle, bottom left, saved by Murphy, Maddie. Shot by WVU Vallerand, Julianne, bottom center, saved by Messner, Morgan. Shot by PSU MacBean, Kaitlyn, bottom center, saved by Murphy, Maddie. WVU substitution: Aunkst, Mackenzie for Sparacio, Leah. WVU substitution: Heredia-Beltran, Dilary for Loza, Isabel. WVU substitution: Rodriguez, AJ for White, Taylor. WVU substitution: Murphy, Maddie for Massey, Kayza. PSU substitution: Kershner, Elle for Wheeler, Ellie. PSU substitution: Messner, Morgan for Asman, Katherine. PSU substitution: Olive, Devon for Wilson, Natalie. PSU substitution: Canniff, Jordan for Dyke, Cori. PSU substitution: Hiatt, Cassandra for Wiesner, Kate. PSU substitution: Wasserman, Rachel for Alonso, Eva. PSU substitution: Jennings, Jillian for Schiemann, Mieke. GOAL by PSU White, Amelia Assist by Schiemann, Mieke and Wiesner, Kate. WVU substitution: Scott, Aaliyah for McCarthy, Lilly. PSU substitution: Smith, Olivia for Hocking, Penelope. PSU substitution: White, Amelia for Linnehan, Payton. PSU substitution: MacBean, Kaitlyn for Schlegel, Ally. WVU substitution: Loza, Isabel for Rodriguez, AJ. ![]() GOAL by PSU Hocking, Penelope Assist by Wiesner, Kate and Schiemann, Mieke. WVU substitution: Heredia-Beltran, Dilary for Sparacio, Leah. WVU substitution: McCarthy, Lilly for Loza, Isabel. ![]() WVU substitution: Segalla, Lauren for Adler, Chloe. WVU substitution: McCutcheon, Maya for Leslie, Annika. WVU substitution: Rodriguez, AJ for Scott, Aaliyah. WVU substitution: Bilal, Aria for White, Taylor. PSU substitution: Wilson, Natalie for Wasserman, Rachel. PSU substitution: Wiesner, Kate for White, Amelia. PSU substitution: Hocking, Penelope for MacBean, Kaitlyn. PSU substitution: Linnehan, Payton for Olive, Devon. PSU substitution: Schlegel, Ally for Smith, Olivia. WVU substitution: Leslie, Annika for McCutcheon, Maya.įOR WVU:, #00 Massey, Kayza, #1 Bilal, Aria, #4 Rodriguez, AJ, #8 Robinson, Gabrielle, #10 Brewster, Jordan, #12 McCutcheon, Maya, #14 Segalla, Lauren, #15 McCarthy, Lilly, #18 Heredia-Beltran, Dilary, #23 Moreau, Maddie, #26 Vallerand, Julianne.įOR PSU:, #26 Asman, Katherine, #23 Alonso, Eva, #5 Dyke, Cori, #34 Schlegel, Ally, #10 Myers, Maddie, #12 Linnehan, Payton, #16 Wheeler, Ellie, #18 Hocking, Penelope, #25 Schiemann, Mieke, #6 Wiesner, Kate, #32 Wilson, Natalie. ![]() Shot by WVU Vallerand, Julianne, out left. WVU substitution: Sparacio, Leah for Heredia-Beltran, Dilary. WVU substitution: Adler, Chloe for Segalla, Lauren. PSU substitution: Wasserman, Rachel for Schlegel, Ally. PSU substitution: MacBean, Kaitlyn for Hocking, Penelope. WVU substitution: Scott, Aaliyah for Rodriguez, AJ. PSU substitution: White, Amelia for Wilson, Natalie. PSU substitution: Olive, Devon for Linnehan, Payton. PSU substitution: Alonso, Eva for Jennings, Jillian. WVU substitution: Loza, Isabel for McCarthy, Lilly. PSU substitution: Smith, Olivia for Wiesner, Kate. WVU substitution: White, Taylor for Bilal, Aria. Shot by WVU Segalla, Lauren, bottom center, saved by Asman, Katherine. GOAL by PSU Linnehan, Payton Assist by Wiesner, Kate and Wilson, Natalie. Massey, Kayza at goalie for West Virginia |
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